PhD student

MSc

Biosketch

• Bachelor’s Degree in Biomedical Engineering – Politecnico di Milano (Sept 2014 – Sept 2017) 

• Master’s Degree in Biomedical Engineering, “Biomechanics and Biomaterials”, Politecnico di Milano, Milan, Italy (Sept 2017 – April 2020)

• International Erasmus Mobility, Universität Politècnica de València, Valencia, Spain (Sept 2018 – Feb 2019) 

• PhD in Biomedical Sciences, University of Bern, Bern, Switzerland (July 2020 – present)

 Research interests

• NMR Spectroscopy

• Metabolomics

• Cell culture

• Respirometry

Projects

• Determination of Intra- and Extracellular Metabolic Adaptations of 3D Cell Cultures upon Challenges in Real-Time by NMR

• In Real-Time Longitudinal Metabolomic Study of Living Perfused Intact and Deficient Human Skin Fibroblasts

• Proton T1 Inversion Recovery and Spatially Resolved T1 Estimation for the Determination of the Average and Spatially Resolved Oxygen along the InsightCell Tube Length

• Investigation of Bioenergetics and Metabolism in Living Cells: a Comparison Between NMR Bioreactor and Seahorse Analyzer

• Metabolic Profiling of Urine in Healthy Volunteers by 1H-NMR: Determination and Reduction of Within-subject Variability

• Enhancement of Non-Exchangeable NAD+ Proton Signals by Minimizing Water Protons Perturbation by Frequency-Selective NAD+ Excitation

 Funding

Supported by the Swiss National Science Foundation (Nr. 310030_192691) and a grant from the Batzebär foundation of the Children’s University Hospitals Bern

 Prizes and awards

• Scholarship for students with particular high merits by the Politecnico di Milano - 2018/2019

• Scholarship to support the international mobility both by the Politecnico and the European Union - 2018/2019

 Selected publications

• Urzì C., Hertig D., Meyer C., Maddah S. Nuoffer J.M., Vermathen P., “Determination of Intra- and Extracellular Metabolic Adaptations of 3D Cell Cultures upon Challenges in Real-Time by NMR”, Int. J. Mol. Sci., 2022 https://www.mdpi.com/1422-0067/23/12/6555/htm