Johannes Slotboom



Starting 1986 at the Delft University of Technology, Johannes Slotboom (PhD) worked in the field of Magnetic Resonance Imaging and Spectroscopy ever since. Within the in vivo MR-field he worked on hardware related topics like eddy-current compensation, automatic B0-shimming, the development of adiabatic pulse sequences for localized in vivo MR-spectroscopy (1991), studying the effects of RF-pulses on J-coupled spin systems (1994) spectral quantification. He received his PhD in 1993. After his PhD he worked a year at Philips Medical Systems on a simulation program for selective RF-pulses and the integration of 2D-selective RF-pulses into the scanner software. 

From 1994-1999 he worked as a research fellow at the AMSM at the University Bern further focusing on spectral quantification applied to 1H-muscle MRS and localized MRS of the human heart, and MRS of X-nuclei (31P, 13C and 23Na) including hetero-nuclear decoupling, with applications to the liver and muscle. He was the co-inventor of a method for the restoration of electro-physiological signals distorted by inductive effects of magnetic field gradient switching during the signal acquisition phase of MR-pulse sequences. Since 2002 he works as a researcher at the Institute for Diagnostics and Interventional Neuroradiology of the University Hospital Bern, Switzerland. His main focus is on the clinical application of MR-spectroscopy in neuroradiology. In this context he worked on a protocol for quantitative clinical routine neuro-MRS, and the  application of machine learning to automatic quality control of in vivo MRSI data. He also worked in the field of texture parameter analysis of MR-perfusion weighted imaging applied to glioma grading, and differentiation of multiple sclerosis lesions, and for the differential diagnosis of enhancing lesions in the brain. Finally he published a feasibility study in the field of localized hypothermia for the treatment of acute ischemic stroke.

He was involved in multiple Swiss National Foundation funded projects (as main, or co-applicant), as was involved in EU-funded projects in the past as invited researcher in the FAST project focusing on the development of dedicated plug-ins for clinical MRS within the software package jMRUI. He was co-applicant in the EU-funded TRANSACT project which was recently closed, and is co-investigator in the Horizon-2020 funded project INSPiRE-MED which will tentatively start in March 2019.


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